Hyperinsulinemia in PRIP-1 Gene Deleted Mice
نویسندگان
چکیده
منابع مشابه
Male mice with deleted Wolframin (Wfs1) gene have reduced fertility
BACKGROUND Wolfram Syndrome (WS) is an autosomal recessive disorder characterised by non-autoimmune diabetes mellitus, optic atrophy, cranial diabetes insipidus and sensorineural deafness. Some reports have described hypogonadism in male WS patients. The aim of our study was to find out whether Wfs1 deficient (Wfs1KO) male mice have reduced fertility and, if so, to examine possible causes. ME...
متن کاملNOMO-1 gene is deleted in early-onset colorectal cancer
To characterize clinical features of a recurrent alteration in 16p13.12-p13.11 in Colorectal Cancer (CRC), mainly in Early-onset subgroup (EOCRC), and to assess the status of NOMO1, a gene located in that region, we analyzed differential clinicopathological, familial and molecular features of CRC subsets with and without alterations in the 16p13.12-p13.11, in global and EOCRC groups. We confirm...
متن کاملA codon 129 polymorphism in the PRIP gene.
Source/Description: The polymerase chain reaction (PCR) and allele specific oligonucleotide (ASO) hybridisation were used to detect a common polymorphism within the open reading frame (ORF) of the human prion protein (PRIP) gene. This polymorphism has previously been reported as a mutation (1). The oligonucleotide sequences for amplification of the ORF of the PRIP contained EcoRI and BamHI link...
متن کاملDLC 1 ( deleted in liver cancer 1 )
DLC1 was first isolated from human hepatocellular carcinoma (HCC) by PCR-based subtractive hybridization method in 1998 (Yuan et al., 1998). It maps to human chromosome 8p21.3-22, a region recurrently deleted in HCC and other solid tumors. Several isoforms of DLC1 have been found, namely DLC1alpha (isoform 2), DLC1beta (isoform 1) and DLC1gamma (isoform 3). DLC1alpha, DLC1beta and DLC1gamma con...
متن کاملLeptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice.
Leptin controls feeding behavior and insulin secretion from pancreatic beta-cells. Insulin stimulates the production of leptin, thereby establishing an adipoinsular axis. Earlier we identified leptin receptors on pancreatic beta-cells and showed leptin-mediated inhibition of insulin secretion by activation of ATP-sensitive potassium channels. Here we examine transcriptional effects of leptin on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Research
سال: 2001
ISSN: 0388-6107,1880-313X
DOI: 10.2220/biomedres.22.157